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Friday, August 25, 2000

Pharmacology MCQ Explanation 109

Friday, August 25, 2000

The Correct Answer is B. Probenecid

Probenecid is indicated for the long-term management of hyperuricemia associated with chronic gout . It is recommended only for patients whose 24-hour renal excretion of urate is 800 mg (4.8 mmol) or lower (i.e., patients who are hyperuricemic as a result of underexcretion, rather than overproduction, of urate) .

The aim of probenecid therapy is to reduce the number of acute gout attacks. Probenecid is a uricosuric agent. By competitively inhibiting the active reabsorption of urate at the proximal renal tubule, it increases the urinary excretion of uric acid and lowers serum urate concentrations. By lowering serum concentrations of uric acid below its solubility limits , probenecid may decrease or prevent urate deposition, tophi formation, and chronic joint
changes; promote resolution of existing urate deposits; and, after several months of therapy, reduce the frequency of acute attacks of gout .

Probenecid has no anti-inflammatory or analgesic
activity .


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